In this introduction to antimicrobial stewardship, Audry Hawkins first lists untoward effects of antibiotic use. She then describes antibiotic stewardship principles, goals, and strategies. After, she recognizes changes in the regulatory roadmap and national landscape of antimicrobial stewardship over the past few years, including requirements for accreditation for stewardship programs. Lastly, she identifies proven benefits of antimicrobial steward ship; and finally, Sarah Moore reviews the available local and state-level resources.